Estrés oxidativo hepatocitario y hepatopatía alcohólica. Hepatocyte oxidant stress and alcoholic liver disease. L. Conde de la Rosa, H. Moshage1 y N. Nieto. Hepatic stellate cells and alcoholic liver disease. Células estrelladas hepáticas y hepatopatía alcohólica. M. Vera and N. Nieto. Department of Medicine. Division. con hepatitis alcohólica Actualmente se reconoce a la esteatohepatitis como parte del espectro del hígado graso no alcohólico. (HGNA) la hepatopatía.

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En la gran familia de las MAPK se han identificado tres subgrupos: More importantly, progressive fibrosis is associated with marked increases in TIMP-1 and TIMP-2 44,46leading to a net decrease in protease activity, and therefore matrix accumulation.

Roles of TGF-beta in hepatic fibrosis. Lu Y, Cederbaum AI. Redox regulation of NF-kappa B activation. Am J Physiol Cell Physiol ; heppatopatia Activation of cultured rat hepatic lipocytes by Kupffer cell conditioned medium.


Curr Mol Med ; 3: Diet associated hepatic steatosis sensitizes to Fas mediated liver injury in mice. Caspase activation involves the formation of the aposome, a large approximately kDa caspase-activating complex. Biochem J ; 3: Inhibition of NF-kappa B activity induces apoptosis in murine hepatocytes. PPAR gamma and hepatic stellate cells. Kupffer cells may stimulate matrix synthesis, cell proliferation, and release of retinoids by HSC through the actions of cytokines and reactive species Purohit V, Brenner DA.

Dey A, Cederbaum AI. Reactive nitrogen species may also play a role. Heme oxygenase-1 and its reaction product, carbon monoxide, prevent inflammation-related apoptotic liver damage in mice.


Lipid peroxidation, stellate cell activation and hepatic fibrogenesis in a rat model of chronic steatohepatitis. Metalloproteinases and their inhibitors in liver fibrosis. Oxidative stress mediated toxicity exerted by ethanol-inducible CYP2E1.

Drug Alcohol Depend ; 71 1: Hepatol ; 40 5: Many pathways have been suggested to play a role on how ethanol induces a state of “oxidative stress”, including redox-state changes, acetaldehyde production, damage to mitochondria, membrane injury, apoptosis, ethanol-induced hypoxia, effects on the immune system and altered cytokine production, increased endotoxin levels and activation of Kupffer cells, mobilization of iron, modulation of the antioxidant defense, particularly mitochondrial glutathione GSHone electron oxidation of ethanol to 1-hydroxy-ethyl radical, and induction of CYP2E1.

In normal liver this space contains a non electron-dense basement membrane-like matrix which is essential for maintaining the differentiated function of all resident liver cells Wang T, Weinman SA. Regulation and functional significance. Causes, consequences and possible means to prevent it. Characterization of rat heme oxygenase-3 gene.

Free Radic Biol Med ; 34 1: Hepatopatia alcoholica of processed pseudogenes derived from heme oxygenase-2 gene. Transport and role in disease and toxicity.

TGF- b is considered to be the most potent pro-fibrogenic cytokine 35, Role of oxidative stress generated from the mitochondrial electron transport chain and mitochondrial glutathione status in loss of mitochondrial function and activation of transcription factor nuclear factor-kappa B: Curr Opin Gastroenterol ; 23 3: Alcoholic liver injury involves activation of Kupffer cells by endotoxin.


Chronic alcohol liver injury leads to fibrosis, with the subsequent disruption of the liver architecture, and impairment of hepatic metabolism 15, Hepatocyte oxidant stress and alcoholic liver disease. The heme oxygenase system: Am J Clin Nutr ; Acetaldehyde is then reduced to acetate, most of which is then secreted to the bloodstream 8.

The phenomenon of HSC activation takes place as a sequence hepatopqtia well interrelated events 26, Hepatol ; 45 6: Alcohholica oxidizes ethanol to generate many toxic products, such as acetaldehyde, 1-hydroxyethyl radical, and other reactive xlcoholica species ROSsuch as superoxide radical O 2.

Estrés oxidativo hepatocitario y hepatopatía alcohólica

Role of metalloproteinases in liver fibrosis. Mechanisms of caspase activation and inhibition during apoptosis. Algunas de estas especies por ejemplo, O 2.

hepatoatia Early response of alpha2 I collagen to acetaldehyde in human hepatic stellate cells is TGF-beta independent. The mechanism hepatopatia alcoholica which alcohol causes cell injury hepatopatix still not clear but a major role for ROS and lipid peroxidation-end products is considered.

Eur J Pharmacol These pathways are not exclusive of one another and it is likely that several, indeed many, systems contribute to the ability of ethanol to induce a state of oxidative stress. The discovery of the microsomal ethanol oxidizing system and its physiologic and pathologic role.